COMPLEMENT ACTIVATION, LIPID METABOLISM, AND MITOCHONDRIAL INJURY: CONVERGING PATHWAYS IN AGE-RELATED MACULAR DEGENERATION

Complement activation, lipid metabolism, and mitochondrial injury: Converging pathways in age-related macular degeneration

The retinal pigment epithelium (RPE) is the primary site of injury in non-neovascular age-related macular degeneration or dry AMD.Polymorphisms in genes that regulate complement activation and cholesterol metabolism are strongly associated with AMD, but the biology underlying disease-associated variants is not well understood.Here, we highlight rec

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SIMULATION OFTHERMO-ELASTICS PROPERTIESOFTHERMALBARRIERCOATINGS

Thermal barrier coatings are used to protect different parts in compressors and turbines from heat.They are generally composed of two layers, one metallic layer providing resistance to heat corrosion and oxidation, and one thermally insulating ceramic layer.Two different techniques are industrially used.Plasma spray results in 3m speedglas 9002nc a

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Chemotherapy-elicited exosomal miR-378a-3p and miR-378d promote breast cancer stemness and chemoresistance via the activation of EZH2/STAT3 signaling

Abstract Background Not all breast cancer (BC) patients who receive neoadjuvant chemotherapy achieve a pathologic complete response (pCR), but the reasons for this are unknown.Previous studies have shown that exosomes produced in the tumor microenvironment in response to chemotherapy promote a chemotherapy-resistant phenotype in tumors.However, the

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