Complement activation, lipid metabolism, and mitochondrial injury: Converging pathways in age-related macular degeneration
The retinal pigment epithelium (RPE) is the primary site of injury in non-neovascular age-related macular degeneration or dry AMD.Polymorphisms in genes that regulate complement activation and cholesterol metabolism are strongly associated with AMD, but the biology underlying disease-associated variants is not well understood.Here, we highlight rec